The p Globin 3 ' Enhancer Element Confers Regulated Expression on the Human y Globin Gene in the Human Embryonic - Fetal Erythroleukemia Cell Line K 562
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چکیده
We have constructed fusion genes comprised of y and p globin elements and globin sequences linked to neomycin resistance (neon) genes to define the cis acting sequences responsible for developmental stage-specific expression and induction of fetal globin genes in embryonic-fetal erythroleukemia K562 cells. The results indicate that the y promoter is required for proper initiation of transcription. However, the accumulation of y globin transcripts in response to hemin
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تاریخ انتشار 2003